In a shock move which would deliver a stunning statement of intent, the beaten Champions League finalists are ready to spend big in a bid to deliver the silverware the club's supporters crave.
Spurs officials have spoken to their counterparts in Turin over the 25-year-old striker and are ready to break their own transfer record - set earlier this summer - to bring him to north London.
Dybala, an Argentina international, is regarded as one of the best forwards in the world and his capture would be regarded as a huge coup for Mauricio Pochettino.
He has suffered from the arrival of Cristiano Ronaldo at Juventus, scoring just 10 goals last season, and the Italians are thought to be prepared to listen to offers.
While a successful move - which would smash the £65m agreed with Lyon for Tanguy Ndombele earlier this month - is regarded as ambitious, Spurs are serious about exploring the possibility of bringing Dybala to the club and setting up what could become a fearsome partnership with Harry Kane in the process.
It can be disclosed that initial contact was made around a month ago, and the fascinating prospect remains on the radar as chairman Daniel Levy looks to back his manager - although Manchester United and Paris Saint-Germain are both reported to be in the running.